The connection between COVID-19 and Hydroxychloroquine

Know about Hydroxychloroquine how it helps to treat covid.

In response to the growing interest worldwide regarding the potential use of Hydroxychloroquine in treating and preventing COVID-19 disease, brought on by the viral SARS-CoV-2, we review the latest evidence guidelines on whether Hydroxychloroquine is a miracle drug that can save lives in this epidemic.

What is Hydroxychloroquine?

It is a DMARD (disease-modifying drug (DMARD) that has a chemical structure similar to chloroquine. It can be used to treat rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Before the release of more modern agents, it was also employed to treat and prevent malaria.

Since chloroquine isn't available in Australia as of yet, this report will focus on it until chloroquine is mentioned within the study of clinical studies or international guidelines. Chloroquine has not been marketed in Australia even though it was approved by the Therapeutic Goods Administration (TGA) in 1991 for the prevention as well as treatment for malaria, for treatment of amoebic hepatitis, and to treat certain types in SLE, RA, and related collagen disorders.

Hydroxychloroquine acts as an immunomodulator instead of an immunosuppressant. It may reduce the CRS (CRS) or "cytokine storm" - an inflammation that is triggered due to activation in the immune system through the reduction of CD154 Expression in the T-cell.

Immune modulation is one of the reasons why researchers are studying Hydroxychloroquine as a prevention and treatment of cytokine storms in COVID-19.

Long-term safety statistics

Long-term safety data are obtained from the observations of patients taking it to treat approved conditions like RA or SLE. There aren't any long-term safety studies regarding using it for COVID-19.

At present, the possibility of long-term exposure to Hydroxychloroquine is only feasible if it is tested as a prophylactic treatment for a long time against COVID-19.

There are numerous clinical studies (up to 12-weeks) investigating the effectiveness and safety of Hydroxychloroquine prevention before and after exposure to COVID-19.

What happens if you interact with other medications?

Hydroxychloroquine buy online UK may be incompatible with monoamine-oxidase inhibitors (MAOIs).

Because Hydroxychloroquine extends the QT interval, it is not recommended for patients taking other medications known to lengthen the QT interval. For instance, antiarrhythmics of Class IA and III tricyclic antidepressants and Antipsychotics and some antibiotics include azithromycin because of the increased risk of arrhythmias of the ventricular region.

Other medications in combination with Hydroxychloroquine are antimalarial agents, antidiabetic drugs known to reduce the threshold of convulsions digoxin, and a few antiepileptic medications.

Do you have any evidence to support the use of Hydroxychloroquine for COVID-19?

At present, there is a lack of research studies that confirm its efficacy in the treatment or treatment of COVID-19.

For instance, a small pilot study in China randomly selected 30 patients with COVID-19 confirmed diagnosis to receive a regular treatment or treatment with the drug Hydroxychloroquine. Results were comparable for both groups. After seven days, more patients taking conventional medicine (93.3 percent) had positive throat swabs than those who received Hydroxychloroquine (86.7 percent).

Another study in France found that Hydroxychloroquine on its own (600 mg/day) or when combined with azithromycin (500 mg on the first day and 250 mg/day after that for four days) decreased the detection of SARS-CoV-2 in the upper respiratory tract of specimens when compared to a non-randomized control group.

The study didn't determine the benefits of clinical trials, and the results are not reliable due to the study's limitations. The problem was not randomly randomized. The test's accuracy was inconsistent, and the number of patients required to provide statistical certainty to the results wasn't reached. Patients could not follow up, and there was no possibility of gathering long-term or medium-term data.

The study was not a randomized retrospective study, and, until now, the study has not yet been peer-reviewed. Other limitations were a limited population of predominantly African-American males with a minimum age of 65. The results were adjusted to account for confounders such as comorbidities and medications. However, the authors could not eliminate the possibility of bias due to selection or other confounding factors that remain.